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One gene for folate metabolism comes from each parent and dictates the activity of an enzyme called MTHFR or methyl-tetrahydrofolate reductase. If you get two "slow" genes from your parents, something called homozygous MTHFR 677TT, you transform folate to the active form MTHF in reduced amounts. This affects 10% of the population. Jun 10, 2015 · Remember the MTHFR mutation can cause issues in utilizing folate/folic acid and can cause infertility, mid-line defects, developmental issues, difficulties producing neurotransmitters, depression, anxiety, irritability, learning difficulties, detoxification issues, and other complications. If you are planning to have children methylation status ....

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